Points - Recent Research
The Effect of Neiguan Point (P6) Acupressure With Wristband on Postoperative Nausea, Vomiting, and Comfort Level
Effects of Acupuncture on Vascular Dementia (VD) Animal Models
Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line

The Effect of Neiguan Point (P6) Acupressure With Wristband on Postoperative Nausea, Vomiting, and Comfort Level

Ünülü M, et al.

PURPOSE: To determine how usage of wristband acupressure at pericardium 6 (P6) Neiguan point application affects nausea, vomiting, and comfort level in the postoperative period.
DESIGN: A randomized controlled experimental study.
METHODS: The study was implemented at an obstetrics hospital. The study was conducted on 97 patients (47 experimental and 50 control subjects) who underwent gynecologic surgery other than caesarian section. In the experimental group, wristband acupressure was applied during the first 12 hours after operation. The control group received antiemetics during and after operation.
FINDINGS: Although P6 acupressure application was effective at preventing vomiting, its effect on nausea intensity was even better. Also, the P6 acupressure application enhanced patient comfort.
CONCLUSIONS: Because of its effectiveness and feasibility, wristband P6 acupuncture point acupressure application is a great alternative to pharmacologic methods in the gynecologic surgery population.

J Perianesth Nurs. 2018 Dec;33(6):915-927. doi: 10.1016/j.jopan.2017.09.006. Epub 2017 Nov 3.

Source: PubMed

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Effects of Acupuncture on Vascular Dementia (VD) Animal Models

Zhang ZY1, et al.

BACKGROUND: Vascular dementia is the second most common type of dementia that causes cognitive dysfunction. Acupuncture, an ancient therapy, has been mentioned for the treatment of vascular dementia in previous studies. This study aimed to evaluate the effects of acupuncture in animal models of vascular dementia.
METHODS: Experimental animal studies of treating vascular dementia with acupuncture were gathered from Embase, PubMed and Ovid Medline (R) from the dates of the databases' creation to December 2016. We adopted the CAMARADES 10-item checklist to evaluate the quality of the included studies. The Morris water maze test was considered as an outcome measure. The software Stata12.0 was used for the meta-analysis. Heterogeneity was examined using I2 statistics, and we conducted subgroup analyses to determine the causes of heterogeneity for escape latency and duration in original platform.
RESULTS: Sixteen studies involving 363 animals met the inclusion criteria. The included studies scored between 4 and 8 points, and the mean was 5.44. The results of the meta-analysis indicated remarkable differences with acupuncture on increasing the duration in the former platform quadrant both in EO models (SMD = 1.56, 95% CI: 1.02 ~ 2.11; p < 0.00001) and 2-VO models (SMD 4.29, 95% CI 3.23 ~ 5.35; p < 0.00001) compared with the control groups.
CONCLUSIONS: Acupuncture may be effective in improving cognitive function in vascular dementia animal models. The mechanisms of acupuncture for vascular dementia are multiple such as anti-apoptosis, antioxidative stress reaction, and metabolism enhancing of glucose and oxygen.

BMC Complement Altern Med. 2018 Nov 13;18(1):302. doi: 10.1186/s12906-018-2345-z.

Source: PubMed

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Sweroside Alleviated Aconitine-Induced Cardiac Toxicity in H9c2 Cardiomyoblast Cell Line

Ma LQ1, et al.

Abstract
Aconitine is the main bioactive ingredient of Aconitum plants, which are well-known botanical herbs in China. Aconitine is also notorious for its high cardiotoxicity, as it can induce life-threatening ventricular arrhythmias. Unfortunately, there are few effective antidotes to aconitine toxicity. This study aimed to evaluate the potent protective effects of the ingredients from V. baillonii on aconitine toxicity on H9c2 cell line. Cell viability was assessed by methylthiazoltetrazolium bromide (MTT). Intracellular Ca2+ concentration alteration and reactive oxygen species (ROS) generation were observed by confocal microscopy and flow cytometry, respectively. Cellular oxidative stress was analyzed by measuring malondialdehyde (MDA) and superoxide dismutase (SOD) levels. Mitochondrial membrane potential (ΔΨ) was determined using JC-1 kit. RT-PCR and Hoechst staining techniques were conducted to determine the levels of autophagy/apoptosis. The mRNA levels of dihydropyridine receptor (DHPR), ryanodine receptors (RyR2) and sarcoplasmic reticulum Ca2+-ATPase (SERCA) were measured by RT-PCR. We screened six components from V. baillonii, among which, sweroside exhibited the strongest protective effects on aconitine-induced cardiac toxicity. Sweroside suppressed the aconitine-induced mRNA expressions of NaV1.5 (encoded by SCN5A), RyR2 and DHPR, and reversed the aconitine-induced decrease in mRNA level of SERCA, thus preventing the aconitine-induced persistent intracellular Ca2+ accumulation and avoiding intracellular Ca2+ overload. We further found that sweroside restabilized the aconitine-disrupted mitochondrial membrane potential (ΔΨ) and reversed the aconitine-induced increase in the mRNA levels of cell autophagy-related factors (Beclin-1, Caspase-3, and LC3- II) in H9c2 cells. In the whole-animal experiments, we observed that sweroside (50 mg/kg) alleviated effectively aconitine-induced arrhythmias by analysis of electrocardiogram (ECG) recording in rats. Our results demonstrate that sweroside may protect cardiomyocytes from aconitine toxicity by maintaining intracellular Ca2+ homeostasis, restabilizing mitochondrial membrane potential (ΔΨ) and avoiding cell autophagy/apoptosis.

Front Pharmacol. 2018 Oct 25;9:1138. doi: 10.3389/fphar.2018.01138. eCollection 2018.

Source: PubMed

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