Points - Recent Research
Early Age-Related Macular Degeneration Treated with Emayaoling Acupuncture Technique
Effects of Heat-Sensitive Moxibustion on HPA Axis in Rats with Irritable Bowel Syndrome
Herbal Compound Teng-Long-Bu-Zhong-Tang Inhibits Metastasis in Human RKO Colon Carcinoma

Early Age-Related Macular Degeneration Treated with Emayaoling Acupuncture Technique

Li G1, et al.

OBJECTIVE: To compare the differences in the clinical therapeutic effects on early age-related macular degeneration (AMD) in the treatment between emayaoling acupuncture technique and regular acupuncture.
METHODS: A total of 110 patients of AMD were randomized into an observation group (55 cases, 73 eyes) and a control group (55 cases, 76 eyes). In the observation group, acupuncture was applied at Cuanzhu (BL 2) and Yiming (EX-HN 14). The needles were retained for 30 min. Additionally, Ganshu (BL 18), Pishu (BL 20) and Shenshu (BL 23) were stimulated with quick needling technique. Emayaoling needling technique was applied. The needle was rotated with the thumb and index finger of the puncture hand, forward and backward. The strong and large amplitude were given when the thumb moved forward, and while, the week and small amplitude required when moving backward. The gentle movement was required in the entire procedure. In the control group, the point selection was same as the observation group. The points were stimulated with regular technique. The needle retaining time was same as the observation group. The treatment was given once every two days in the two groups and for 3 months continuously. The visit was followed up for 3 months. Before and after treatment, as well as at follow-up, the eyesight, the effect on macular area and the macular retinal structure [the macular nerve fiber layer (MNFL), retinal neurepithelium layer (RNL), pigment epithelium and choroid capillary composite lay (PECCL)] were evaluated separately.
RESULTS: 1. After treatment and at follow-up, the eyesight was improved as compared with that before treatment in the two groups, indicating the significant difference (both P<0.05). The differences in comparison before and after treatment, and in comparison of the follow-up with that before treatment, were improved in a larger amplitude in the observation group as compared with the control group, indicating the significant difference (both P<0.05). 2. Regarding the therapeutic effects on macular area, after treatment and at follow-up, the total effective rates were 83.6% (61/73) and 86.3% (63/73) in the observation group and were 63.2% (48/76) and 67.1% (51/76) in the control group separately. The results in the observation group were higher than those in the control group, indicating the significant difference between the two groups (both P<0.05). 3. Regarding the macular retinal structure, after treatment and at follow-up, the levels of MNFL, RNL and PECCL were all reduced as compared with those before treatment, indicating the significant difference (all P<0.05). After treatment and at follow-up, the levels of MNFL, RNL and PECCL in the observation group were all lower than those in the control group, indicating the significant difference (all P<0.05).
CONCLUSION: The emayaoling acupuncture technique achieves better clinical therapeutic effects on treatment of early AMD as compared with the regular acupuncture.

Zhongguo Zhen Jiu. 2017 Dec 12;37(12):1294-8. doi: 10.13703/j.0255-2930.2017.12.011.

Source: PubMed

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Effects of Heat-Sensitive Moxibustion on HPA Axis in Rats with Irritable Bowel Syndrome

Zhang H1, et al.

OBJECTIVE: To observe the effects of heat-sensitive moxibustion on corticotropin releasing hormone (CRH), adrenocorticotrophic hormone (ACTH) and corticosterone (CORT) in rats with irritable bowel syndrome (IBS), and to explore the possible mechanism of heat-sensitive moxibustion on IBS.
METHODS: According to random number table, 56 SD male rats were randomly divided into a blank group (n=8), a model group (n=8), a moxibustion group (n=32), and a mifepristone group (RU-486 group, n=8). The rats in the blank group were treated with normal feeding; the rats in the model group, RU-486 group and moxibustion group were treated with chronic non-predictable stimulation for 21 days to establish IBS model. After model establishment, the rats in the moxibustion group were treated with moxibustion at "Mingmen" (GV 4) for 40 min, once a day for 14 days; the tail temperature was recorded every 5 min; according to the change of tail temperature, the rats were divided into a heat-sensitive moxibustion group and a non-heat-sensitive moxibustion group, and 8 rats were randomly selected in the two groups. The rats in the RU-486 group were treated with gastric administration of RU-486 for 14 days, while the rats in the blank group, model group and moxibustion groups were treated with identical volume of 0.9% NaCl. The rat general condition, body mass, behavioristics, intestinal propulsive rate and visceral sensitivity were observed in each group; ELISA method was used to detect serum CRH, ACTH and CORT; optical microscope was applied to observe the morphological changes of colon.
RESULTS: (1) After model establishment, rats were in rest state, fatigued, with withered hair and dim ear; the stool was dry or watery; the body mass were slowly increased; the number of crossed grid and standing frequency were significantly reduced; visceral sensitivity was increased and intestinal propulsion rate was decreased; no obvious inflammatory cell infiltration was observed under microscope. (2) After intervention, compared with the blank group, the body mass and visceral sensitivity in the RU-486 group were not significantly different (both P>0.05), but the intestinal propulsion rate was decreased significantly (P<0.01). Compared with the blank group, the body mass of heat-sensitive moxibustion group and non-heat-sensitive moxibustion group was lower (both P<0.01), but the visceral sensitivity and intestinal propulsion rate were similar (both P>0.05). Compared with the model group, the body mass and visceral sensitivity were improved in the RU-486 group (P<0.05, P<0.01), but the intestinal propulsion rate was similar (P>0.05). The body mass, visceral sensitivity and intestinal propulsion rate of the heat-sensitive moxibustion group and the non-heat-sensitive moxibustion group were superior to those of the model group (P<0.05, P<0.01), and the body mass and intestinal propulsion rate of heat-sensitive moxibustion group were superior to those of non-heat-sensitive moxibustion group (both P<0.05). (3) After intervention, compared with the blank group, the contents of CRH, ACTH and CORT in the model group were significantly increased (P<0.05, P<0.01). Compared with the model group, the contents of CRH, ACTH and CORT of the heat-sensitive moxibustion group were statistically reduced (P<0.05, P<0.01), and the contents of CRH and ACTH in the non-heat-sensitive moxibustion group were statistically reduced (P<0.05, P<0.01); the content of CRH in the RU-486 group was reduced (P<0.05), but the contents of ACTH and CORT were increased (P<0.05, P<0.01). Compared with the non-heat-sensitive moxibustion group, the heat-sensitive moxibustion group was better in the improvement of CRH (P<0.05), but there was no significant difference of ACTH and CORT between the two groups (both P>0.05).
CONCLUSION: Heat-sensitive moxibustion could reduce the contents of CRH, ACTH and CORT through the HPA axis, and improve the function of gastrointestinal motility to treat IBS.

Zhongguo Zhen Jiu. 2017 Dec 12;37(12):1315-21. doi: 10.13703/j.0255-2930.2017.12.016.

Source: PubMed

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Herbal Compound Teng-Long-Bu-Zhong-Tang Inhibits Metastasis in Human RKO Colon Carcinoma

Wei MM1,2,3, et al.

Metastasis is one of the primary obstacles to the successful treatment of colorectal cancer. Teng-Long-Bu-Zhong-Tang (TLBZT) is a modern Chinese herbal formula that may be useful in the treatment of metastatic colorectal cancer. The present study evaluated the effects of TLBZT on lung metastasis in human RKO colon carcinoma cells injected into mice via the tail vein. The results demonstrated that TLBZT inhibited the metastasis of human RKO colon carcinoma cells to the lungs. TLBZT downregulated the expression of LOX and hypoxia-inducible factor 1α. TLBZT also inhibited the expression of integrins αV and β3 and the phosphorylation of focal adhesion kinase. These results indicate that TLBZT inhibits the lung metastasis of RKO colon carcinoma by regulating the expression of multiple genes. The results of the present study provide a new basis for the management of colorectal cancer metastasis using treatments derived from Chinese herbs.

Oncol Lett. 2017 Dec;14(6):7767-7772. doi: 10.3892/ol.2017.7206. Epub 2017 Oct 18.

Source: PubMed

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